Programmable and
Interactive Materials
The Sitt Research Group
School of Chemistry,
Sackler Faculty of Exact Sciences
In our lab, we study how chemical and physical information can be incorporated into nano and microscale systems, and what is the relationship between information, structure and function.
Our research interests include:
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Stimuli responsive micro and nanosystems
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1-D to 3-D folding in the nanoscale
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Reversible self-assembly
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Chemical reactions in confined environments
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Multi-compartmental organic and inorganic nanoparticles
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Chemical information in micro and nanoscale systems
March 12, 2021
Together with the Adler-Abramovich Lab, we introduced a composite scaffold composed of polycaprolactone and hyaluronic acid incorporated with a short self-assembling peptide. The peptide includes the arginine-glycine-aspartic acid (RGD) motif and supports cellular attachment based on molecular recognition. In vitro assays revealed preosteoblasts adhered well to the scaffold and proliferated with significant osteogenic differentiation and calcium mineralization, making this system a leading candidate to serve as a scaffold for bone tissue engineering.
March 4, 2021
We demonstrate a general scheme for fabricating freestanding Metal–organic frameworks (MOFs)-embedded polymeric fibers, in which the fibers themselves act as microreactors for the in situ growth of the MOF crystals. We demonstrate that immobilizing enzymes on such MOF-polymer fibers improves their performance and enhances the enzyme's stability.
